1.An ST1 has prepared a presentation regarding the appendix.Which of the following statements mentioned by him during the presentation is incorrect?

2.Ovarian fossa is a small depression on the lateral pelvic wall where the ovary rests.Which of the following structure does not contribute to formation of the ovarian fossa?

3.While repairing a 4th degree perineal tear,following an obstetric trauma,the colorectal surgeon is called in to repair the tear.Trauma to the anal mucosa above which level needs to be repaired by a colorectal surgeon.

4. which of the following describes the number of chromosomes & amount of DNA in a gamete?

5.In the production of male gametes,which of the following cells remains dormant for 12 years?

6.Fetal sex can be determined by noting the presence or absence of the Barr body in cells obtained from amniotic fluid.What is the etiology of the Barr body?

7. Under anaerobic condition, the pyruvate is converted to lactate leading to muscle cramps. The clearance of accumulated lactate in skeletal muscles is taken care by which metabolic pathway?

8.Number of ATP synthesised in TCA cycle to oxidized one molecule of glucose is

9. The apolipoprotein which acts as a ligand for the HDL receptor is –

10. A 40 year old woman presents with endometrial carcinoma. Her family history reveals that her mother died of endometrial cancer at age of 50, while her 42 year old brother was recently diagnosed with colon cancer. You begin to suspect a familial cancer syndrome. What gene is most likely to be mutated in this family?

11. With regards to vulval carcinoma, which of the following is true?

12. A 14 year old girl presents with prolonged bleeding from wounds after minor trauma & severe menorrhagia. Family history reveals that her father also has prolonged bleeding from wounds after minor trauma, as does her brother. Which of the following is the most likely mechanism of this patient’s disorder?

13.A 32-year-old woman is 15 weeks pregnant with her second pregnancy. She opts to have antenatal screening and has blood taken as part of the quadruple test. The result shows reduced levels of α-fetoprotein and unconjugated oestriol with elevated β-human chorionic gonadotrophin. Which of the following is the most likely explanation for the screening results:

14. A 29-year-old woman seeks genetic counselling as she has a number of her female relatives who have had either breast or ovarian cancer. Both her mother and her sister have been diagnosed with breast cancer. DNA sequencing subsequently shows that she carries a mutated form of the BRCA1 gene.Via which mode of inheritance is the BRCA1 gene mutation transmitted?

15. 46 XY karyotype is associated with which of the following condition?

16. A 34-year-old woman delivers a male baby with Down’s syndrome. Chromosomal analysis following his birth is suggestive of familial Down’s syndrome. What chromosomal event best describes the aetiology of Familial Down’s syndrome?

17. For drugs to be eliminated they undergo metabolism in the liver. The enzyme that takes part in this phase 1 metabolism process is

18. A 25-year-old nulliparous woman, with a lifelong history of tonic clonic seizures, sees her neurologist as she wishes to start a family. In addition to her current anticonvulsant therapy which additional drug is now required?

19. Lignocaine is used for its local anaesthetic effect. Toxicity is seen if there is overdose of the drug. The signs of toxicity are all except?

20. A 27-year-old woman attends antenatal clinic at 32 weeks’ gestation complaining of gradually increasing shortness of breath through pregnancy. Although you feel it is important to exclude serious pathology, you are aware that this could be a normal symptom of advancing pregnancy. Which of the following changes occur in normal pregnancy?

21. A 33-year-old woman attends antenatal clinic at 33 weeks’ gestation complaining of shortness of breath.Which of the following causes a shift of oxygen dissociation to the left?

22. What percentage of the cardiac output is received by the gravid uterus at term pregnancy?

23 .Which nucleus of the hypothalamus secretes Dopamine & GHRH?

24.You are in the gynecology clinic & a 16 year old presents with primary amenorrhea.On investigations her FSH is found to be appropriate for her age.Among the conditions given below,in which condition would you expect to see normal levels of FSH?

25.In nephrogenic diabetes insipidus the clinical picture is of diuresis.Which of the following statements is true in this context?